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Showing 1–3 of 3 results
Advanced filters: Author: "Hugo Lavoie" Clear advanced filters

  • Activation of the RAF protein is key to the RAS–MAPK signalling pathway, and involves the SMP protein complex. Structures for SMP shed light on the process, and suggest fresh targets for anticancer drug discovery.

    • Hugo Lavoie
    • Marc Therrien
    News & Views
    Nature
    Volume: 609, P: 248-249

  • The efficacy of the anticancer drug vemurafenib, which is used to treat metastatic melanoma, is plagued by acquired resistance. A picture of how such resistance develops is emerging. See Letter p.387

    • Hugo Lavoie
    • Marc Therrien
    News & Views
    Nature
    Volume: 480, P: 329-330

  • RAF family kinases, which were first described over 30 years ago, primarily act as signalling relays downstream of RAS. Key mechanistic and structural studies are shaping our view of how RAF proteins and RAF-related pseudokinases are regulated; they also highlight the mechanisms underlying pathological RAF signalling and the unforeseen limitations of RAF inhibitors.

    • Hugo Lavoie
    • Marc Therrien
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 281-298