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Showing 1–11 of 11 results
Advanced filters: Author: "Hui Zhao" Clear advanced filters

  • Pauci-immune crescentic glomerulonephritis is usually a manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. However, some patients with pauci-immune crescentic glomerulonephritis lack ANCA. This Review compares the prevalence, clinical manifestations, histopathology, and outcomes of ANCA-negative pauci-immune crescentic glomerulonephritis with that of ANCA-positive disease. The authors also discuss the possible pathogenesis of ANCA-negative pauci-immune crescentic glomerulonephritis, paying particular attention to the mechanisms and role of neutrophil activation.

    • Min Chen
    • Cees G. M. Kallenberg
    • Ming-Hui Zhao
    Reviews
    Nature Reviews Nephrology
    Volume: 5, P: 313-318

  • Accumulating evidence indicates that activation of the complement system is crucial for the development of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This Review provides an overview of the role of complement activation in AAV, and discusses how targeting this pathway can provide opportunities for treatment.

    • Min Chen
    • David R. W. Jayne
    • Ming-Hui Zhao
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 359-367

  • In this Consensus Statement, a group of experts propose that high-quality immunoassays, rather than indirect immunofluorescence, should be used as the primary screening method for detecting anti-neutrophil cytoplasmic antibodies when diagnosing patients with suspected granulomatosis with polyangiitis or microscopic polyangiitis.

    • Xavier Bossuyt
    • Jan-Willem Cohen Tervaert
    • Elena Csernok
    ReviewsOpen Access
    Nature Reviews Rheumatology
    Volume: 13, P: 683-692

  • The antithyroid drug propylthiouracil has been recognized to cause antineutrophil cytoplasmic antibody-associated vasculitis (AAV). This disease shares some characteristics with primary AAV although important differences do exist. The authors of this Review discuss the pathogenesis, risk factors, diagnosis and treatment of propylthiouracil-induced AAV and also outline the similarities and differences between propylthiouracil-induced AAV and primary AAV.

    • Min Chen
    • Ying Gao
    • Ming-Hui Zhao
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 476-483

  • Antiglomerular basement membrane (anti-GBM) disease is an autoimmune disorder that presents as raised titers of antibodies against the GBM, mostly together with rapidly progressive glomerulonephritis and pulmonary hemorrhage. This Review summarizes current knowledge on the prevalence, clinical manifestations, treatment and outcomes of human anti-GBM disease, and discusses advances in our understanding of its pathogenesis.

    • Zhao Cui
    • Ming-Hui Zhao
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 697-705

  • Current treatment recommendations for lupus nephritis are largely guided by the 2003 International Society of Nephrology/Renal Pathology Society classification system. Here, the authors discuss potential approaches by which this classification system could be improved through consideration of underlying disease processes characterized by the presence of glomerular crescents, podocyte injury, tubulointerstitial lesions and vascular injury.

    • Feng Yu
    • Mark Haas
    • Ming-Hui Zhao
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 483-495

  • This paper provides new insights into the potential therapeutic effects of vitamin E on COPD. The authors show that vitamin E relieves chronic obstructive pulmonary disease (COPD) by negatively regulating the EGFR/MAPK pathway and inhibiting COX2-mediated translocation of phosphorylated STAT3 to the nucleus. Moreover, overexpression of COX2 reverses the protective effect of vitamin E in a rat model of COPD.

    • Hui Zhao
    • Jiannan Gong
    • Jianqiang Li
    Research
    Laboratory Investigation
    Volume: 102, P: 272-280