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Showing 1–3 of 3 results
Advanced filters: Author: "Husseini Manji" Clear advanced filters
  • Despite the clear need for better therapies for psychiatric disorders such as depression and schizophrenia, novel drugs — particularly those that could revolutionize treatment — have been rare in recent years. Following a symposium in which the underlying reasons for this problem were discussed, a group of experts from across the field of neuroscience highlight key advances in our understanding of psychiatric disorders, and propose steps that can be taken to improve the effectiveness of drug discovery in this field.

    • Yves Agid
    • György Buzsáki
    • Daniel Weinberger
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 189-201
  • A public–private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common role of amyloid precursor protein in the two conditions.

    • Seth Ness
    • Michael Rafii
    • Husseini Manji
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 11, P: 655-656
  • A growing body of evidence suggests that many psychiatric illnesses are associated with impaired mitochondrial function. Manji and colleagues review evidence from studies in animal models and humans and discuss strategies for therapeutics aimed at enhancing mitochondrial function in patients with psychiatric disorders.

    • Husseini Manji
    • Tadafumi Kato
    • Guang Chen
    Reviews
    Nature Reviews Neuroscience
    Volume: 13, P: 293-307