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Showing 1–5 of 5 results
Advanced filters: Author: "Ivan Ahel" Clear advanced filters

  • PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 trapping and contributes to inhibitor tolerance.

    • Evgeniia Prokhorova
    • Florian Zobel
    • Ivan Ahel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.

    • Johannes Gregor Matthias Rack
    • Qiang Liu
    • Ivan Ahel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Structural and mechanistic data of the ADP-ribosyltransferase DarT demonstrate the role of ADP-ribosylation of DNA by this enzyme in generating toxicity and regulating cellular signalling processes in bacteria.

    • Marion Schuller
    • Rachel E. Butler
    • Ivan Ahel
    Research
    Nature
    Volume: 596, P: 597-602