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Showing 1–5 of 5 results
Advanced filters: Author: "Ivan Huc" Clear advanced filters

  • Molecules that mimic the charge surface of B-DNA could enable the inhibition of DNA processive enzymes. Now, helically folded aromatic oligoamide scaffolds have been synthesized that display anions at positions similar to that of B-DNA phosphates. These foldamer mimics can recognize some DNA binding proteins and inhibit enzymes such as HIV integrase and topoisomerase 1.

    • Krzysztof Ziach
    • Céline Chollet
    • Ivan Huc
    Research
    Nature Chemistry
    Volume: 10, P: 511-518

  • The extent to which peptide synthesis by the ribosome can tolerate the inclusion of non-peptidic components is not clear. Yet such hybrids would expand the range of ribosomally synthesized structures. Now it has been shown that tRNAs acylated by aromatic foldamers can initiate the ribosomal synthesis of non-cyclic and cyclic foldamer–peptide hybrid molecules. The oligo-aryl segments contain folding information that can control peptide conformation in the hybrids.

    • Joseph M. Rogers
    • Sunbum Kwon
    • Ivan Huc
    Research
    Nature Chemistry
    Volume: 10, P: 405-412

  • The majority of discrete structures obtained by self-assembly possess high symmetry, and thus low complexity: all subunits relate to their neighbours in a similar manner. Now, the spontaneous formation of complex low-symmetry assemblies produced from a single building block has been demonstrated using a systems chemistry approach. The single building block oligomerizes to form specific homomeric cyclic macromolecules that adopt a folded conformation.

    • Charalampos G. Pappas
    • Pradeep K. Mandal
    • Sijbren Otto
    Research
    Nature Chemistry
    Volume: 12, P: 1180-1186