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Showing 1–6 of 6 results
Advanced filters: Author: "Ivan Marazzi" Clear advanced filters

  • Influenza A virus (IAV) infection induces transcription termination defects in host cells, an effect modulated by SUMOylation of an intrinsically disordered region of the influenza NS1 protein expressed by the 1918 pandemic IAV strain.

    • Nan Zhao
    • Vittorio Sebastiano
    • Ivan Marazzi
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 885-893

  • Mutations in the gene encoding the helicase senataxin have well established associations with the neurodegenerative disease ALS. Marazzi et al. show that senataxin can also attenuate virus-triggered responses by controlling RNA polymerase activity at genes encoding antiviral molecules.

    • Matthew S Miller
    • Alexander Rialdi
    • Ivan Marazzi
    Research
    Nature Immunology
    Volume: 16, P: 485-494

  • An immune signature characterized by activated antigen-specific CD8 T cells is identified in the brain and blood of mice with amyotrophic lateral sclerosis-4 (ALS4), suggesting that the immune system is involved in ALS4 neurodegeneration.

    • Laura Campisi
    • Shahab Chizari
    • Ivan Marazzi
    Research
    Nature
    Volume: 606, P: 945-952

  • Gene expression programmes that are induced by inflammatory or oncogenic signals are controlled by shared chromatin regulators. Such chromatin dependencies are known to regulate oncogenes and inflammation-promoting genes and can be leveraged to combine and increase the effectiveness of immune-cell-based therapies with epigenetic therapies.

    • Ivan Marazzi
    • Benjamin D. Greenbaum
    • Ernesto Guccione
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 245-261

  • This Review outlines the gene and protein expression strategies used by viruses to expand the efficiency of their coding and regulatory sequences, and the implications of these mechanisms for developing antiviral agents.

    • Jessica Sook Yuin Ho
    • Zeyu Zhu
    • Ivan Marazzi
    Reviews
    Nature
    Volume: 593, P: 362-371