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  • Genome-wide association studies have recently furthered the understanding of the genetics of osteoporosis. The authors here present the major findings from these studies, the pathways that have been highlighted in the progress of the disease and strategies for future diagnosis and therapy development.

    • J. Brent Richards
    • Hou-Feng Zheng
    • Tim D. Spector
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 576-588

  • Genetic architecture describes the characteristics of genetic variation that are responsible for phenotypic variability. This Review discusses the types of genetic architecture that have been observed, how they can be measured and how genetic architecture informs the scientific and clinical goals of human genetics.

    • Nicholas J. Timpson
    • Celia M. T. Greenwood
    • J. Brent Richards
    Reviews
    Nature Reviews Genetics
    Volume: 19, P: 110-124