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Showing 1–3 of 3 results
Advanced filters: Author: "J D Isaacs" Clear advanced filters

  • Here, John Isaacs describes the societal implications of rheumatoid arthritis and how diagnosis and treatment approaches have evolved. He also discusses the future approaches needed for the complete management of this disease.

    • John D. Isaacs
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 10, P: 605-611

  • The use of biologic agents has revolutionized treatment in a number of rheumatic and non-rheumatic autoimmune and inflammatory disorders. In this Review, the authors discuss whether rheumatologists can learn lessons from the application of biologic agents in non-rheumatic diseases such as psoriasis, asthma and multiple sclerosis.

    • Gillian M. Bell
    • Gary Reynolds
    • John D. Isaacs
    Reviews
    Nature Reviews Rheumatology
    Volume: 7, P: 507-516

  • Clinical use of biologic therapies for rheumatology has revealed that efficacy, toxicity and pharmacodynamic effects can deviate from those predicted. In this review, Issacs and colleagues summarize lessons gleaned from practical experience and discuss how these can inform future development of new biologic therapies.

    • Vibeke Strand
    • Robert Kimberly
    • John D. Isaacs
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 75-92