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Showing 1–3 of 3 results
Advanced filters: Author: "J Gay" Clear advanced filters

  • Lipopolysaccharide (LPS) from Gram-negative bacteria is a potent activator of the innate immune response. Clare Bryant and colleagues discuss recent exciting data that have revealed the structural basis of the recognition of LPS by the Toll-like receptor 4–MD2 complex.

    • Clare E. Bryant
    • David R. Spring
    • Nicholas J. Gay
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 8-14

  • Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream.

    • Laurie J. Gay
    • Brunhilde Felding-Habermann
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 123-134

  • In this Review, the authors describe how Toll-like receptors (TLRs) assemble with signalling adaptor proteins to form higher-order scaffolds that signal in response to pathogen sensing. Productive TLR signalling involves cooperative assembly, post-translational modification and subcellular localization of the components of the signalling complexes.

    • Nicholas J. Gay
    • Martyn F. Symmons
    • Clare E. Bryant
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 546-558