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  • Multiplication of repetitive DNA sequences is often the cause of neurodegenerative diseases. A four-stranded structure has been found to form in one such expansion in the gene C9orf72, altering gene function in four ways. See Article p.195

    • J. Paul Taylor
    News & Views
    Nature
    Volume: 507, P: 175-177

  • Expansions of repeat sequences cause some of the most common inherited neurological diseases. But how do repeats in DNA lead to pathogenesis? This Review considers the diverse mechanisms that are now emerging, including aberrant splicing, post-translational modification and autophagy.

    • Albert R. La Spada
    • J. Paul Taylor
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 247-258