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Showing 1–6 of 6 results
Advanced filters: Author: "J Quinn" Clear advanced filters

  • The heterodimeric cytokine IL-27 consists of the subunits p28 and EBI3. Hunter and colleagues demonstrate that p28 acting alone can inhibit the signaling of many cytokines by interfering with the common receptor gp130.

    • Jason S Stumhofer
    • Elia D Tait
    • Christopher A Hunter
    Research
    Nature Immunology
    Volume: 11, P: 1119-1126

  • The screening of natural products for lead molecules is an attractive strategy, as most natural products fall within biologically relevant chemical space. In this Review, Harvey, Edrada-Ebel and Quinn discuss how advanced screening, metabolomics and metagenomics approaches can be used in the identification, validation and production of naturally sourced compounds, and highlight examples of naturally derived antimicrobials and inhibitors of protein–protein interactions.

    • Alan L. Harvey
    • RuAngelie Edrada-Ebel
    • Ronald J. Quinn
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 111-129

  • Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.

    • Jeffrey J Quinn
    • Howard Y Chang
    News & Views
    Nature Genetics
    Volume: 46, P: 929-931

  • In their battle for survival, soil microorganisms produce a vast arsenal of toxic molecules. One such toxin contains a unique sequence of atoms, and its biosynthesis includes some unexpected steps.

    • John P. Quinn
    News & Views
    Nature
    Volume: 448, P: 415-416

  • Long non-coding RNAs (lncRNAs) are a class of RNAs with great molecular and regulatory diversity. This Review discusses how, beyond their lack of protein-coding potential, some types of lncRNAs are known to exhibit features that are distinct from mRNAs, including their transcriptional regulation, localization, processing, biological capabilities and degradation. Such properties underlie many of the key cellular functions of lncRNAs.

    • Jeffrey J. Quinn
    • Howard Y. Chang
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 47-62