Bacterial degradative proteases are essential for growth and survival, representing attractive targets for the development of novel antibacterials. However, despite pharmaceutical successes with protease modulators in several diseases, this class of enzymes has not yet been targeted to treat bacterial infections. Here, Rubin and colleagues review the biological roles of key prokaryotic degradative proteases, highlighting recent advances and challenges in their therapeutic exploitation.
- Ravikiran M. Raju
- Alfred L. Goldberg
- Eric J. Rubin
