The role of antineutrophil cytoplasmic antibodies (ANCA) in the development of the pauci-immune vasculitide Churg–Strauss syndrome is unclear. Chemmalakuzhy et al. report the case of a 36-year-old man diagnosed with Churg–Strauss syndrome, whose presentation was notable for two atypical features: first, the absence of asthma and second, the presence of glomerulonephritis in the absence of ANCA. The latter observation challenges current thinking about the role of ANCA in the pathogenesis of the syndrome.
- Asha J Chemmalakuzhy
- Xin J Zhou
- S Susan Hedayati
