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Showing 1–4 of 4 results
Advanced filters: Author: "J Silvio Gutkind" Clear advanced filters

  • G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their potential as therapeutic targets.

    • Robert T. Dorsam
    • J. Silvio Gutkind
    Reviews
    Nature Reviews Cancer
    Volume: 7, P: 79-94

  • Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Recent deep sequencing studies have shown that nearly 20% of human tumours harbour mutations in GPCRs. This Analysis article reviews these findings and the indications that G proteins, GPCRs and their signalling pathways represent novel therapeutic targets for cancer prevention and treatment.

    • Morgan O'Hayre
    • José Vázquez-Prado
    • J. Silvio Gutkind
    Research
    Nature Reviews Cancer
    Volume: 13, P: 412-424

  • Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and β-catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

    • Julie Gavard
    • J. Silvio Gutkind
    News & Views
    Nature Cell Biology
    Volume: 10, P: 883-885