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Showing 1–15 of 15 results
Advanced filters: Author: "J. Turner" Clear advanced filters

  • Mucosal associated invariant T (MAIT) cells reside in barrier organs, but their contribution to inflammatory processes in the kidneys is not fully known. Here authors find by single cell RNA sequencing that among the different MAIT cell subtypes found at steady state, a population with MAIT17 signature is expanded in both human crescentic glomerulonephritis and its mouse model, and these cells may play protective role in the disease.

    • Ann-Christin Gnirck
    • Marie-Sophie Philipp
    • Jan-Eric Turner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The identification of a specific subpopulation of immune-system T cells that drives type 1 diabetes provides insight into the development of autoimmune disease, and could point the way to new therapies.

    • Stephen J. Turner
    • Nicole L. La Gruta
    News & Views
    Nature
    Volume: 602, P: 35-36

  • Catalysts working in pairs can promote more-effective reactions than can the same catalysts used sequentially. The coupling of an enzyme with a light-activated catalyst offers great potential for organic synthesis.

    • Nicholas J. Turner
    News & Views
    Nature
    Volume: 560, P: 310-311

  • How is it that biofilms are less susceptible to metal toxicity than exponentially growing planktonic cell populations? Here, Harrison and colleagues propose a multifactorial model of biofilm multimetal resistance and tolerance by which biofilms can withstand metal toxicity by an ongoing process of cellular diversification within the microbial population.

    • Joe J. Harrison
    • Howard Ceri
    • Raymond J. Turner
    Reviews
    Nature Reviews Microbiology
    Volume: 5, P: 928-938

  • A nanopore DNA sequencer is used for real-time genomic surveillance of the Ebola virus epidemic in the field in Guinea; the authors demonstrate that it is possible to pack a genomic surveillance laboratory in a suitcase and transport it to the field for on-site virus sequencing, generating results within 24 hours of sample collection.

    • Joshua Quick
    • Nicholas J. Loman
    • Miles W. Carroll
    Research
    Nature
    Volume: 530, P: 228-232

  • The recent development of a broad range of biocatalysts that can be applied in organic synthesis has brought into focus the need to rethink the way in which organic target molecules might be constructed in the future. To aid synthetic chemists in identifying where biocatalysts might be usefully applied, we propose that guidelines and rules for 'biocatalytic retrosynthesis' be developed and that this new approach be embedded in the future training and education of organic chemists.

    • Nicholas J Turner
    • Elaine O'Reilly
    Comments & Opinion
    Nature Chemical Biology
    Volume: 9, P: 285-288

  • The global rise of antibiotic resistance and the paucity of novel antimicrobial compounds in the pipeline have revived interest in the use of metals as antimicrobial agents. Here, Lemire, Harrison and Turner describe the principles of metal toxicity, the uptake of metals by microbial cells and the distinct types of cellular damage that they cause. They also discuss the use of metal-based agents as antimicrobials.

    • Joseph A. Lemire
    • Joe J. Harrison
    • Raymond J. Turner
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 371-384

  • Outsourcing has been relatively rare in academia until now, but is that beginning to change?

    • Franz B Pichler
    • Susan J Turner
    Comments & Opinion
    Nature Biotechnology
    Volume: 25, P: 1093-1096

  • Antigen-specific T-cell responses are often characterized by the preferred use of certain T-cell receptors (TCRs). This Review describes when and how this might occur, with particular focus on the structural constraints that determine binding of a TCR to its ligand.

    • Stephen J. Turner
    • Peter C. Doherty
    • Jamie Rossjohn
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 883-894