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Showing 1–12 of 12 results
Advanced filters: Author: "J. Wade Harper" Clear advanced filters

  • Host cells battle invading bacteria using a degradation process facilitated by the protein ubiquitin. The discovery of the host enzyme responsible and its bacterial target reveals that this process defies convention.

    • Brenda A. Schulman
    • J. Wade Harper
    News & Views
    Nature
    Volume: 594, P: 28-29

  • The attachment of ubiquitin-like proteins (UBLs) to proteins is a central mechanism of modulation of protein function. Enzymatic, structural and genetic studies have elucidated how mechanistically and structurally related E1 enzymes activate UBLs and selectively direct them to downstream pathways.

    • Brenda A. Schulman
    • J. Wade Harper
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 319-331

  • An absolute quantification approach combined with differential affinity capture provides a means by which to accurately measure distinct pools of ubiquitin in cells or tissues.

    • Eric J Bennett
    • J Wade Harper
    News & Views
    Nature Methods
    Volume: 8, P: 630-631

  • Low-complexity protein aggregates are a hallmark of neurodegeneration. High-resolution snapshots of the structure of one such aggregate offer an unprecedented view of how these proteins disrupt crucial cellular functions.

    • Laura Pontano Vaites
    • J. Wade Harper
    News & Views
    Nature
    Volume: 555, P: 449-451

  • Environmental pollutants such as dioxins affect human health. It now seems that dioxins exert their effect by forming atypical enzyme complexes that mediate the breakdown of steroid-hormone receptors.

    • J. Wade Harper
    News & Views
    Nature
    Volume: 446, P: 499-500

  • The study of fast and intricate enzyme reactions requires methods that have the speed and sophistication to match. Such an approach reveals the way in which proteins are tagged with ubiquitin for destruction.

    • Malavika Raman
    • J. Wade Harper
    News & Views
    Nature
    Volume: 462, P: 585-586

  • A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment. This approach sets the stage for systems-level analyses of the dynamics of the mammalian proteome.

    • Xiaolu L Ang
    • J Wade Harper
    News & Views
    Nature Chemical Biology
    Volume: 5, P: 9-11

  • Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.

    • John R Lydeard
    • J Wade Harper
    News & Views
    Nature Biotechnology
    Volume: 28, P: 682-684

  • The deubiquitylating enzyme Dub3 is found to have oncogenic potential by stabilizing the Cdc25A protein phosphatase, a crucial regulator of cell-cycle progression.

    • Sebastian D. Hayes
    • J. Wade Harper
    News & Views
    Nature Cell Biology
    Volume: 12, P: 311-313

  • DNA damage activates signaling cascades driven by the ATM–ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.

    • Eric J Bennett
    • J Wade Harper
    News & Views
    Nature Structural & Molecular Biology
    Volume: 15, P: 20-22

  • The ubiquitin–proteasome pathway contains a large number of components that are possible drug targets for cancer and other diseases. Nalepaet al. review evidence linking components of this pathway to human disease and discuss potential strategies for therapeutic intervention.

    • Grzegorz Nalepa
    • Mark Rolfe
    • J. Wade Harper
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 596-613

  • The enzyme parkin is known to promote disposal of organelles called mitochondria that have suffered damage. The identification of an enzyme that opposes parkin demonstrates how a delicate balance is maintained in the cell. See Article p.370

    • Alban Ordureau
    • J. Wade Harper
    News & Views
    Nature
    Volume: 510, P: 347-348