Restenosis of atherosclerotic lesions after initial treatment with angioplasty and stenting occurs in around 15% of patients. Although this condition is complex and the causative mechanisms have not yet been fully identified, they are thought to include inflammation, proliferation, and matrix remodeling with some patients being more 'predisposed' to developing restenosis than others. In this Review, Jukema and colleagues evaluate the available evidence on the pathophysiology of restenosis and provide an overview of the various risk factors for this disease.
- J. Wouter Jukema
- Jeffrey J. W. Verschuren
- Paul H. A. Quax
