The pathophysiology of IBD is complex. A number of genetic association studies and findings from research consortia have identified a large number of IBD susceptibility genes. Here, the authors describe available evidence on the genetics of IBD, and how this data can be used to inform our understanding of the disease itself, including insights into the functional consequences and how they provide novel therapeutic targets or disease biomarkers.
- Johan Van Limbergen
- Graham Radford-Smith
- Jack Satsangi
