Nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatits can take decades to evolve and progress, which limits the quality of longitudinal data. Researchers have, therefore, turned their attention to the development of suitable animal models to test the role of molecules and molecular pathways in the progression of fatty liver formation. This Review discusses the benchmark animal models that recapitulate the pathology and metabolic dysfunction associated with NALFD.
- Lionel Hebbard
- Jacob George