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Showing 1–14 of 14 results
Advanced filters: Author: "Jacob Hanna" Clear advanced filters

  • Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.

    • Danna Sheinboim
    • Itay Maza
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • This study shows that the combination of naive pluripotency growth conditions, Oct4, Sox2, Klf4 and Myc (OSKM) overexpression, and depleting the Mbd3/NuRD co-repressor results in deterministic and synchronized reprogramming to pluripotency.

    • Yoach Rais
    • Asaf Zviran
    • Jacob H. Hanna
    Research
    Nature
    Volume: 502, P: 65-70

  • It is known that human embryonic stem (ES) cells are more similar to mouse primed epiblast stem cells than to naive mouse ES cells; here culture conditions are determined that allow human ES and induced pluripotent stem cells to acquire a pluripotent state that retains growth characteristics highly similar to mouse naive ES cells, and competence in generating cross-species human-mouse embryonic chimaerism.

    • Ohad Gafni
    • Leehee Weinberger
    • Jacob H. Hanna
    Research
    Nature
    Volume: 504, P: 282-286

  • The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up to 13–14 days after fertilization.

    • Bernardo Oldak
    • Emilie Wildschutz
    • Jacob H. Hanna
    ResearchOpen Access
    Nature
    Volume: 622, P: 562-573

  • Inactivation of the major histocompatibility complex and overexpression of the transmembrane protein CD47 renders induced pluripotent stem cells invisible to the immune system of the host.

    • Tom Shani
    • Jacob H. Hanna
    News & Views
    Nature Biomedical Engineering
    Volume: 3, P: 337-338

  • There are two methods for reprogramming mature cells to pluripotent stem cells, which can give rise to all cells of the body. The first direct comparison of the methods reveals that both can cause subtle molecular defects. See Article p.177

    • Vladislav Krupalnik
    • Jacob H. Hanna
    News & Views
    Nature
    Volume: 511, P: 160-162

  • When human blastocysts are cultured in vitro to derive embryonic stem cells, they undergo profound molecular changes that alter their identity.

    • Ariel Pribluda
    • Jacob H Hanna
    News & Views
    Nature Biotechnology
    Volume: 30, P: 247-249

  • How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

    • Noa Novershtern
    • Jacob H. Hanna
    News & Views
    Nature Cell Biology
    Volume: 13, P: 886-888

  • Recent advances in our understating of the molecular underpinnings of alternative primed- and naive-like pluripotent states in rodents and humans highlight potential functional benefits of naive pluripotency and identify key unanswered questions in this rapidly evolving field.

    • Leehee Weinberger
    • Muneef Ayyash
    • Jacob H. Hanna
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 155-169