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Showing 1–7 of 7 results
Advanced filters: Author: "Jacques Neefjes" Clear advanced filters

  • New work explains how the interferon-γ-regulated GTPase Irgm1 on phagosomes responds to intracellular signaling and recruits the 'machinery' for fusion with lysosomes. This pathway overlaps a signaling route controlled by bacteria to prevent the fusion of phagosomes with lysosomes.

    • Coenraad Kuijl
    • Jacques Neefjes
    News & Views
    Nature Immunology
    Volume: 10, P: 808-809

  • Major histocompatibility complex class II molecules present peptides to CD4+ T cells. New findings indicate that conventional and plasmacytoid dendritic cells handle these molecules differently after activation.

    • Tineke van den Hoorn
    • Jacques Neefjes
    News & Views
    Nature Immunology
    Volume: 9, P: 1208-1210

  • Since the definition of an immunoselective proteasome, the 'immunoproteasome', its function has been heavily disputed. A mouse with complete deficiency in immunoproteasomes has resolved one issue of the adaptation of the immune system to the proteasome but has raised other questions.

    • Robbert M Spaapen
    • Jacques Neefjes
    News & Views
    Nature Immunology
    Volume: 13, P: 109-111

  • In addition to viruses, bacteria such asHelicobacter pylori and Salmonella enterica subsp. entericaserovar Typhi have been linked to cancer development. Progress has been made in our understanding of how bacterial effectors contribute to cancer directly by influencing host cell signalling pathways and indirectly by causing tissue damage and inflammatory responses.

    • Aurélie Gagnaire
    • Bertrand Nadel
    • Jean-Pierre Gorvel
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 109-128