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Showing 1–4 of 4 results
Advanced filters: Author: "James E. Darnell" Clear advanced filters

  • Inspiration and innovation in molecular cancer research.

    • David A. Foster
    • James E. Darnell Jr
    News & Views
    Nature
    Volume: 458, P: 718

  • The passage of transcription factors in and out of the nucleus must be regulated for their proper function. Surprisingly, regulation of nuclear trafficking among members of the signal transducer and activator of transcription (STAT) family differs, revealing specific targets for therapeutic intervention.

    • Nancy C. Reich
    • Ling Liu
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 602-612

  • Advances in the understanding of the genetic and environmental causes of schizophrenia, and their relationship to aberrant patterns of neurodevelopment, have led to growing interest in the possibility that 'disease-modifying' strategies could alter the course to — and of — this debilitating disorder, rather than just alleviating its symptoms. This article provides a broad-based consideration of the challenges and opportunities inherent in such efforts.

    • Mark J. Millan
    • Annie Andrieux
    • Daniel Weinberger
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 485-515