Molecular analysis has transformed our current understanding of the etiology of papillary thyroid carcinoma (PTC). Activating mutations of components of the mitogen-activated protein kinase signal transduction pathway, including the serine/threonine kinase B-RAF, are frequently detected. The prognostic significance of theseBRAFmutations and the therapeutic implications for managing PTC are discussed.
- Lionel Groussin
- James A Fagin
