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Showing 1–5 of 5 results
Advanced filters: Author: "James H. Hurley" Clear advanced filters

  • New observations of ESCRT-mediated reverse-topology membrane scission are building towards a structural and biophysical explanation of the mechanism involved.

    • Johannes Schöneberg
    • Il-Hyung Lee
    • James H. Hurley
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 5-17

  • This Progress article looks at recent developments in our understanding of the role of the host factor Alix in both retroviral and cellular membrane budding and fission events.

    • Ken Fujii
    • James H. Hurley
    • Eric O. Freed
    Reviews
    Nature Reviews Microbiology
    Volume: 5, P: 912-916

  • The endosomal sorting complex required for transport (ESCRT) machinery catalyses membrane budding in the endolysosomal pathway, which differs from other budding events in that it is directed away from the cytosol. Recent studies have elucidated a mechanism whereby ESCRT-I and ESCRT-II stabilize the bud neck and ESCRT-III mediates neck cleavage.

    • James H. Hurley
    • Phyllis I. Hanson
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 556-566

  • HIV-1 avoids the immune detection of infected cells by preventing class I molecules of the major histocompatibility complex (MHC-I) bound to viral peptides from reaching the cell surface. A new structure shows how Nef turns MHC-I from a noncargo into a cargo for the clathrin adaptor AP-1, thus directing MHC-I to the lysosome instead of the plasma membrane.

    • James H Hurley
    • Juan S Bonifacino
    News & Views
    Nature Structural & Molecular Biology
    Volume: 19, P: 661-662

  • Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

    • James H. Hurley
    • Greg Odorizzi
    News & Views
    Nature Cell Biology
    Volume: 14, P: 654-655