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Showing 1–2 of 2 results
Advanced filters: Author: "James Inglese" Clear advanced filters

  • Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

    • James Inglese
    • Caroline E Shamu
    • R Kiplin Guy
    Comments & Opinion
    Nature Chemical Biology
    Volume: 3, P: 438-441

  • The recent growth in the number of academic drug discovery centres is providing new opportunities to couple the curiosity-driven research culture in academia with rigorous preclinical drug discovery practices used in industry. To realize the potential of these opportunities, it is important that academic researchers understand the risks in several key areas — including organization, target selection, assay design, medicinal chemistry and preclinical pharmacology — which are discussed in this article.

    • Jayme L. Dahlin
    • James Inglese
    • Michael A. Walters
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 279-294