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Showing 1–7 of 7 results
Advanced filters: Author: "James J Collins" Clear advanced filters

  • Bacterial responses to antibiotics are complex and involve many genetic and biochemical pathways. This Review describes the effects of bactericidal antibiotics on bacterial cellular processes, the associated responses that contribute to killing and recent insights into these processes revealed through the study of biological networks.

    • Michael A. Kohanski
    • Daniel J. Dwyer
    • James J. Collins
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 423-435

  • In this Timeline article, Collins and colleagues chart the history of synthetic biology since its inception just over a decade ago, with a focus on both the cultural and scientific progress that has been made as well as on key breakthroughs and areas for future development.

    • D. Ewen Cameron
    • Caleb J. Bashor
    • James J. Collins
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 381-390

  • Advances in the synthetic biology field are allowing an expansion beyond small gene networks towards larger biological programs that hold promise for a wide range of applications, including biosensing, therapeutics and the production of biofuels, pharmaceuticals and biomaterials.

    • Ahmad S. Khalil
    • James J. Collins
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 367-379

  • Two studies find that programmable RNA-processing tools counter the problem of context-dependence in the construction of synthetic biology circuits.

    • Caleb J Bashor
    • James J Collins
    News & Views
    Nature Biotechnology
    Volume: 30, P: 1061-1062

  • Despite our continued efforts to assert control over pathogens, more and more bacteria are saying “no” to drugs. It is becoming increasingly apparent that microbial environments, influenced by intracellular and extracellular metabolic processes, modulate antibiotic susceptibility in bacteria. A deeper understanding of these environmental processes may prove crucial for the development of new antibacterial therapies.

    • Henry H Lee
    • James J Collins
    Comments & Opinion
    Nature Chemical Biology
    Volume: 8, P: 6-9

  • Synthetic biology approaches to characterize gene regulation have largely used transcription factor circuits in bacteria. However, the multilayered regulation of genes by chromatin in eukaryotes provides opportunities for more sophisticated control of gene expression. This Review describes diverse approaches for engineering eukaryotic chromatin states, the insights gained into physiological gene regulation principles, and the broad potential applications throughout biomedical research and industry.

    • Albert J. Keung
    • J. Keith Joung
    • James J. Collins
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 159-171