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Showing 1–8 of 8 results
Advanced filters: Author: "Jan Lammerding" Clear advanced filters

  • Lamin mutations responsible for muscular dystrophy are shown to reduce nuclear envelope stability, resulting in mechanically induced nuclear envelope rupture, DNA damage and activation of DNA damage response pathways that lead to muscle cell death. Preventing nuclear envelope damage by reducing cytoskeletal forces on the nucleus improves muscle fibre health and function.

    • Ashley J. Earle
    • Tyler J. Kirby
    • Jan Lammerding
    Research
    Nature Materials
    Volume: 19, P: 464-473

  • Forces applied to the cell surface induce stretching of the chromatin in the nucleus and a rapid increase in gene expression.

    • Tyler J. Kirby
    • Jan Lammerding
    News & Views
    Nature Materials
    Volume: 15, P: 1227-1229

  • Cells sense their physical surroundings by translating mechanical forces and deformations into biochemical signals. Defects in mechanotransduction are implicated in the development of many diseases, ranging from muscular dystrophies, cardiomyopathies and loss of hearing to cancer progression and metastasis.

    • Diana E. Jaalouk
    • Jan Lammerding
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 63-73

  • Lamin and emerin mutations causing cardiomyopathies are associated with an impairment in actin dynamics, resulting in aberrant nuclear translocation and downstream signalling of the transcription factor MKL1, which is pivotal for cardiac development.

    • Chin Yee Ho
    • Diana E. Jaalouk
    • Jan Lammerding
    Research
    Nature
    Volume: 497, P: 507-511

  • Nuclei are subject to various deformations, being pulled, pushed, squeezed and stretched by a plethora of intracellular and extracellular forces. Recent work is unravelling how nuclei sense and respond to these deformations, including with changes in genome organization and function, cell signalling, and cell mechanics.

    • Yohalie Kalukula
    • Andrew D. Stephens
    • Sylvain Gabriele
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 583-602

  • Mechanical forces influence both cytoplasmic and nuclear events. Kirby and Lammerding discuss recent evidence suggesting that the nucleus itself is a mechanosensor and methods to study nuclear mechanotransduction.

    • Tyler J. Kirby
    • Jan Lammerding
    Reviews
    Nature Cell Biology
    Volume: 20, P: 373-381

  • Cryo-electron tomography has provided a means of characterizing the architecture of macromolecular complexes in their native environment, and facilitated a better understanding of cellular processes. By combining this method with fluorescence and super-resolution microscopy, the full potential of this approach can be realized.

    • Karen Fridman
    • Asaf Mader
    • Ohad Medalia
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 736-742