Metabolic syndrome is associated with increased cancer risk and progression at almost all sites, including the prostate in high-stage prostate cancer, but several reports have described an inverse relationship between metabolic syndrome and its components and low-stage incident prostate cancer. Here, Hammarsten et al. hypothesize that the inverse link between metabolic syndrome and its components and low-stage incident prostate cancer might simply be the result of bias mechanisms.
- Jan Hammarsten
- Jan-Erik Damber
- Ralph Peeker