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Showing 1–21 of 21 results
Advanced filters: Author: "Janet Rossant" Clear advanced filters
  • As the recipients of the 2012 science Nobel prizes gather in Stockholm to celebrate and be celebrated, News & Views shares some expert opinions on the achievements honoured.

    • Janet Rossant
    • Christine Mummery
    News & Views
    Nature
    Volume: 492, P: 56
  • Six scientists in the field of stem cell research comment on our basic understanding of stem cells and other pluripotent cells, on their potential therapeutic use and on key challenges that remain.

    • Cédric Blanpain
    • George Q. Daley
    • Shinya Yamanaka
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 471-476
  • Scientists should carefully consider whether embryo models based on human stem cells are essential to their work because of the associated practical and ethical challenges.

    • Janet Rossant
    • Jianping Fu
    Comments & Opinion
    Nature
    Volume: 622, P: 454-456
  • The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization.

    • Angela C. H. McDonald
    • Janet Rossant
    News & Views
    Nature Cell Biology
    Volume: 16, P: 1128-1129
  • Posfai, Schell, Janiszewski et al. assess candidate totipotent stem cells with in vitro and in vivo assays of increasing stringency to evaluate their developmental potential and lineage contributions.

    • Eszter Posfai
    • John Paul Schell
    • Janet Rossant
    Research
    Nature Cell Biology
    Volume: 23, P: 49-60
  • The early stages of human development are normally hidden within the womb, but improved techniques for culturing embryos from the blastocyst stage promise to make these steps easier to investigate. See Letter p.251

    • Janet Rossant
    News & Views
    Nature
    Volume: 533, P: 182-183
  • Researchers have engineered embryonic stem-like cells from normal mouse skin cells. If this method can be translated to humans, patient-specific stem cells could be made without the use of donated eggs or embryos.

    • Janet Rossant
    News & Views
    Nature
    Volume: 448, P: 260-262
  • Early cell-lineage decisions during embryonic development differ between mice and cows. This finding calls for a re-examination of developmental variations across mammals, but does not undermine use of the mouse as a model organism.

    • Janet Rossant
    News & Views
    Nature
    Volume: 471, P: 457-458
  • Biochemist whose vision of cell signalling transformed cancer research.

    • Alan Bernstein
    • Janet Rossant
    Comments & Opinion
    Nature
    Volume: 501, P: 168
  • International discussion must guide research, urge Nicolas Rivron, Martin Pera and colleagues.

    • Nicolas Rivron
    • Martin Pera
    • Rosario Isasi
    Comments & Opinion
    Nature
    Volume: 564, P: 183-185
  • Wong et al. differentiate human pluripotent stem cells into mature airway epithelial cells expressing CFTR, a gene involved in cystic fibrosis. Applying the method to induced pluripotent stem cells derived from cystic fibrosis patients provides a renewable source of cells for drug screening.

    • Amy P Wong
    • Christine E Bear
    • Janet Rossant
    Research
    Nature Biotechnology
    Volume: 30, P: 876-882
  • In a recent paper in Cell Research, Yu et al. show that maternally inherited Yes-associated protein (Yap), a co-activator of TEAD family transcription factors, plays a key role in activating embryonic transcription following fertilization in the mouse.

    • Eszter Posfai
    • Janet Rossant
    Research Highlights
    Cell Research
    Volume: 26, P: 393-394