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Advanced filters: Author: "Jean-Marc Egly" Clear advanced filters

  • Group A trichothiodystrophy is caused by mutations in the p8 subunit of the TFIIH complex, involved in transcription and nucleotide-excision repair. Now the structure of the yeast ortholog of p8 in complex with a fragment of the yeast ortholog of p52 shows how p8 stabilizes p52 and thus the whole TFIIH complex.

    • Denis E Kainov
    • Marc Vitorino
    • Jean-Marc Egly
    Research
    Nature Structural & Molecular Biology
    Volume: 15, P: 980-984

  • The TFIIH complex has an integral role in both nucleotide excision repair and transcription. Studies of TFIIH are therefore defining a new model for crosstalk between the factors that orchestrate DNA repair and transcription, as well as the concept of 'transcription diseases'.

    • Emmanuel Compe
    • Jean-Marc Egly
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 343-354