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Showing 1–2 of 2 results
Advanced filters: Author: "Jean-Paul Fermand" Clear advanced filters

  • Renal impairment is a common problem in patients with multiple myeloma. An early and rapid reduction in serum levels of free light chains (FLCs), achieved with the use of antimyeloma agents or direct removal of FLCs, has been shown to improve renal recovery in these patients. In this Review, the authors provide an update on new and current management approaches for reducing FLC levels in patients with myeloma-related acute kidney injury.

    • Colin A. Hutchison
    • Joan Bladé
    • Christopher Winearls
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 234-243

  • Patients with acute kidney injury (AKI) complicating multiple myeloma often have poor outcomes. In this Review, Hutchison et al. discuss the pathogenic role of monoclonal free light chains in inducing proximal tubular damage and cast nephropathy in patients with multiple myeloma. The authors also provide an update on the diagnostic approaches to patients with AKI complicating multiple myeloma.

    • Colin A. Hutchison
    • Vecihi Batuman
    • Paul W. Sanders
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 43-51