The Charcot–Marie–Tooth (CMT) neuropathies fall into two main groups: the demyelinating (CMT1) forms, in which nerve conduction velocities are reduced, and the axonal (CMT2) forms, in which nerve conduction velocities are preserved but conduction amplitudes are decreased. In this article, Züchner and Vance review recent advances in our understanding of the genetic and molecular mechanisms that underlie CMT2.
- Stephan Züchner
- Jeffery M Vance