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Showing 1–3 of 3 results
Advanced filters: Author: "Jeffrey A Engelman" Clear advanced filters

  • Insights into the effects of targeted therapies, conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical responses in patients.

    • Philip Gotwals
    • Scott Cameron
    • Glenn Dranoff
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 286-301

  • Phosphatidylinositol 3-kinases (PI3Ks) are members of a unique and conserved family of intracellular lipid kinases that regulate a wide range of biological functions. Our understanding of the intricate regulation of this pathway is being applied to identify therapeutic strategies for diabetes and cancer.

    • Jeffrey A. Engelman
    • Ji Luo
    • Lewis C. Cantley
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 606-619

  • In this Review, the authors examine the aetiological, pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases, the clinical outcomes with targeted therapies, and strategies to discover additional kinases that are activated by chromosomal rearrangements in solid tumours.

    • Alice T. Shaw
    • Peggy P. Hsu
    • Jeffrey A. Engelman
    Reviews
    Nature Reviews Cancer
    Volume: 13, P: 772-787