Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: "Jennifer A. Doudna" Clear advanced filters

  • Recent technological advances have enabled the probing of RNA structure across the transcriptomes of various speciesin vitro and in vivo. This Review discusses our latest understanding of how RNA structure influences various steps of gene expression, including translation, mRNA localization and microRNA-mediated gene regulation.

    • Stefanie A. Mortimer
    • Mary Anne Kidwell
    • Jennifer A. Doudna
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 469-479

  • A bacterial enzyme that uses guide RNA molecules to target DNA for cleavage has been adopted as a programmable tool to site-specifically modify genomes of cells and organisms, from bacteria and human cells to whole zebrafish.

    • Emmanuelle Charpentier
    • Jennifer A. Doudna
    News & Views
    Nature
    Volume: 495, P: 50-51

  • Multiple Argonaute proteins are implicated in gene silencing by RNA interference (RNAi), but only one is known to be an endonuclease that can cleave target mRNAs. Chimeric Argonaute proteins now reveal an unexpected mechanism by which mutations distal to the catalytic center can unmask intrinsic catalytic activity, results hinting at structurally mediated regulation.

    • Mary Anne Kidwell
    • Jennifer A Doudna
    News & Views
    Nature Structural & Molecular Biology
    Volume: 20, P: 769-771

  • The use of CRISPR–Cas technology for gene editing has rapidly become widespread. Here, Corn and colleagues discuss the applications of this revolutionary tool in drug discovery and development, describing how it could make substantial contributions to target identification and validation, animal models and cell-based therapies.

    • Christof Fellmann
    • Benjamin G. Gowen
    • Jacob E. Corn
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 89-100

  • Hepatitis C virus (HCV) uses an internal ribosome entry site (IRES) to directly recruit ribosomes to the viral mRNA translation-start site. Recent structural studies and biochemical data reveal how the HCV IRES interacts with the 40S ribosomal subunit and the cellular protein-synthesis machinery to direct efficient translation initiation.

    • Christopher S. Fraser
    • Jennifer A. Doudna
    Reviews
    Nature Reviews Microbiology
    Volume: 5, P: 29-38

  • Insights into eukaryotic, bacterial and archaeal RNA-based regulatory systems, including microRNAs, small interfering RNAs, clustered regularly interspaced short palindromic repeats (CRISPR) RNA and small RNAs that are dependent on the RNA chaperone protein Hfq, have revealed that they achieve specificity using similar strategies. Specifically, the presentation of short 'seed sequences' within a ribonucleoprotein complex facilitates the search for and recognition of targets.

    • Stanislaw A. Gorski
    • Jörg Vogel
    • Jennifer A. Doudna
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 215-228