Aberrant proliferation is a central hallmark of polycystic kidney diseases (PKDs) but the role of specific G1-phase cyclin-dependent kinases (Cdks) is not clear. This study shows that the kinetics of Cdk2 and Cdk2-cyclin partners do not correlate with proliferation and that the absence of Cdk2 does not alter renal cyst growth, most likely due to compensation by Cdk1. These findings therefore suggest that Cdk2 is not required for the progression of PKD.
- Jennifer Qin Jing Zhang
- Jane Burgess
- Gopala K. Rangan