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Showing 1–5 of 5 results
Advanced filters: Author: "Jenny Hsieh" Clear advanced filters

  • This study uses inducible ablation of NeuroD1 from adult neuronal stem cells/progenitors to show that this transcription factor is crucial for the survival and maturation of adult-born neurons in the hippocampus and olfactory bulb.

    • Zhengliang Gao
    • Kerstin Ure
    • Jenny Hsieh
    Research
    Nature Neuroscience
    Volume: 12, P: 1090-1092

  • Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.

    • Zane R. Lybrand
    • Sonal Goswami
    • Jenny Hsieh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The transcription factor REST plays a crucial role in maintaining the adult neural stem cell pool. To better understand how REST maintains quiescence in neural progenitors, the authors use ChIP-seq and RNA-seq and find that REST regulates represses ribosome biogenesis, cell cycle and neuronal genes.

    • Shradha Mukherjee
    • Rebecca Brulet
    • Jenny Hsieh
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Aberrant hippocampal neurogenesis often occurs after acute seizures that produce epilepsy and cognitive impairment but the role of neurogenesis in the development of epilepsy is unclear. Here the authors suppress adult neurogenesis in mice preceding seizures and show that it reduces subsequent chronic seizure frequency and epilepsy-associated cognitive decline.

    • Kyung-Ok Cho
    • Zane R. Lybrand
    • Jenny Hsieh
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13