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Showing 1–6 of 6 results
Advanced filters: Author: "Jes Olesen" Clear advanced filters

  • A recent study has shown that brain research is poorly funded compared with research in fields such as cancer and heart disease. In this Viewpoint, Jes Olesen discusses possible reasons for this discrepancy, and describes how the European Brain Council is bringing together basic neuroscientists, clinical neurologists and patient organizations to promote brain research and to facilitate the translation of new advances into real benefits for patients.

    • Jes Olesen
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 298-299

  • Classification of migraine into different endophenotypes could aid diagnosis and treatment, but requires detailed characterization of different phenotypes. A new study provides insight into the clinical features of migraine with unilateral cranial autonomic symptoms, but raises questions about the value of such classifications.

    • Jes Olesen
    News & Views
    Nature Reviews Neurology
    Volume: 12, P: 320-321

  • The neural mechanisms of many symptoms associated with migraine have yet to be elucidated. New research suggests that a non-image-forming retinal pathway and signals from the dura mater contribute to photophobia in patients with migraine. More research is needed to understand the mechanisms behind other migraine-associated symptoms such as nausea and osmophobia.

    • Jes Olesen
    News & Views
    Nature Reviews Neurology
    Volume: 6, P: 241-242

  • The benefits of targeting calcitonin gene-related peptide (CGRP) could go beyond migraine prevention, and three new studies report success with a new small-molecule CGRP receptor antagonist in acute migraine and with a monoclonal antibody in cluster headache.

    • Jes Olesen
    • Messoud Ashina
    News & Views
    Nature Reviews Neurology
    Volume: 15, P: 562-564

  • In the ongoing search for new and better migraine treatments, human models have a key role in the discovery of novel targets for antimigraine drugs. This Review summarizes existing experimental models of migraine in humans, and describes the development and use of these models in the identification of key molecular pathways, biomarkers and drug targets.

    • Messoud Ashina
    • Jakob Møller Hansen
    • Jes Olesen
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 713-724

  • Chronic migraine is a severely disabling condition that is poorly recognized and undertreated by clinicians. Much debate has existed over the nomenclature and diagnostic criteria for this condition and, until 2007, there had been a paucity of clinical trial data for preventive therapies. In this Review, Diener and colleagues discuss the evolution of terminology and definitions used for chronic migraine, as well as the epidemiology, pathophysiology and treatment of this condition.

    • Hans-Christoph Diener
    • David W. Dodick
    • Stephen D. Silberstein
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 162-171