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Showing 1–3 of 3 results
Advanced filters: Author: "Jesper Gromada" Clear advanced filters

  • Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4−/− mice on a high-fat diet show improved insulin sensitivity.

    • Viktoria Gusarova
    • Colm O’Dushlaine
    • Jesper Gromada
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.

    • Esther Latres
    • Jason Mastaitis
    • Jesper Gromada
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Over the past 10 years, evidence has accumulated to suggest that α-cells are involved in the development of diabetes mellitus. This Review outlines our current understanding of α-cells and discusses how they could be targeted in the treatment of diabetes mellitus.

    • Jesper Gromada
    • Pauline Chabosseau
    • Guy A. Rutter
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 694-704