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Showing 1–6 of 6 results
Advanced filters: Author: "Joan S Brugge" Clear advanced filters

  • Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.

    • Jonathan L. Coloff
    • Joan S. Brugge
    News & Views
    Nature Cell Biology
    Volume: 19, P: 414-415

  • Reactive oxygen species have been viewed as stress-inducing molecules that promote cancer initiation. But new evidence indicates that oxidative stress can be beneficial — inhibiting the spread of a cancer to other sites. See Article p.186

    • Isaac S. Harris
    • Joan S. Brugge
    News & Views
    Nature
    Volume: 527, P: 170-171

  • The formation and maturation of focal adhesions involves significant changes in protein composition and requires acto-myosin contractility. A mass spectrometry approach reveals changes to the focal adhesion proteome on myosin inhibition, providing a valuable resource for the cell adhesion field.

    • Lisa Gallegos
    • Mei Rosa Ng
    • Joan S. Brugge
    News & Views
    Nature Cell Biology
    Volume: 13, P: 344-346

  • Cancer cells have high levels of reactive oxygen species (ROS) owing to metabolic and genetic alterations. The role of ROS in cancer cells is controversial as they can have both pro-tumorigenic and antitumorigenic properties. In this Review, Mak and colleagues discuss recent findings that cancer cells upregulate antioxidant pathways to counteract ROS, and explore the potential of anticancer strategies that target the antioxidant capacity of tumour cells.

    • Chiara Gorrini
    • Isaac S. Harris
    • Tak W. Mak
    Reviews
    Nature Reviews Drug Discovery
    Volume: 12, P: 931-947

  • In this Review, Miller and colleagues discuss the arsenal of effector proteins that salmonellae use to manipulate their animal hosts, in addition to the host response to these infections. The authors also discuss the challenges ahead for unravelling the mechanistic details of effector function.

    • Doris L. LaRock
    • Anu Chaudhary
    • Samuel I. Miller
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 191-205