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Showing 1–4 of 4 results
Advanced filters: Author: "Joanna Rorbach" Clear advanced filters

  • Structural analysis of several small mitoribosomal subunit intermediates reveals a sequential mechanism of biogenesis, and how assembly links to initiation to form active mitoribosomes.

    • Yuzuru Itoh
    • Anas Khawaja
    • Alexey Amunts
    ResearchOpen Access
    Nature
    Volume: 606, P: 603-608

  • The mammalian mitochondrial genome contains two noncanonical stop codons, AGA and AGG. Here, the authors show that mtRF1, a mitochondrial protein of unknown function, triggers translation termination at AGA or AGG, placing mtRF1 among mitochondrial translation factors.

    • Annika Krüger
    • Cristina Remes
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.

    • Miriam Cipullo
    • Genís Valentín Gesé
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Translation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the roles of mitochondria-specific ribosomal proteins and initiation factors mtIF2 and mtIF3.

    • Anas Khawaja
    • Yuzuru Itoh
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10