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Showing 1–12 of 12 results
Advanced filters: Author: "Johan Auwerx" Clear advanced filters

  • Increased expression of sirtuin proteins has been shown to enhance lifespan in several organisms. New data indicate that some of the reported effects may have been due to confounding factors in experimental design. Here, experts discuss the significance of these data for research into ageing. See Letter p.482

    • David B. Lombard
    • Scott D. Pletcher
    • Johan Auwerx
    News & Views
    Nature
    Volume: 477, P: 410-411

  • Changes in protein or histone acetylation are key integrators of physiological processes such as the circadian clock, cell cycle and gene regulation. In this Review, the authors describe the role of reversible acetylation in metabolic control and how these processes contribute to adaptive cellular and organismal homeostasis. The potential for modulating these pathways as a treatment for various metabolic diseases is also discussed.

    • Keir J. Menzies
    • Hongbo Zhang
    • Johan Auwerx
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 43-60

  • As most mitochondrial proteins are encoded in the nucleus, mitochondrial activity requires efficient communication between the nuclear and mitochondrial genomes. This is mediated by nucleus-to-mitochondria (anterograde), mitochondria-to-nucleus (retrograde) and mitonuclear feedback signalling, as well as the integrated stress response and extracellular communication, which regulate homeostasis and, consequently, healthspan and lifespan.

    • Pedro M. Quirós
    • Adrienne Mottis
    • Johan Auwerx
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 213-226

  • The recent awareness that bile acids act as complex metabolic integrators and signalling factors has led to the recognition of bile-acid signalling as a potential novel therapeutic target in metabolic disease. Thomas and colleagues overview the metabolic roles of bile acids and discuss approaches to modulate their signalling pathways in the treatment of disorders including obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis.

    • Charles Thomas
    • Roberto Pellicciari
    • Kristina Schoonjans
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 678-693

  • Sirtuins are a family of deacetylases that target histones and proteins in several cellular compartments. Sirtuins are crucial regulators of energy homeostasis, as they detect physiological changes in energy levels and modulate glucose and lipid metabolism accordingly. As such, they affect health in a pleiotropic manner.

    • Riekelt H. Houtkooper
    • Eija Pirinen
    • Johan Auwerx
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 225-238

  • Dysfunctional mitochondria are implicated in rare, inherited mitochondrial diseases as well as a variety of common age-related disorders. Here, Auwerx and colleagues provide an overview of diseases that affect mitochondria, highlight strategies for therapeutically intervening in mitochondrial pathways and discuss screening strategies for drug identification.

    • Pénélope A. Andreux
    • Riekelt H. Houtkooper
    • Johan Auwerx
    Reviews
    Nature Reviews Drug Discovery
    Volume: 12, P: 465-483

  • Antidiabetic drugs that activate the protein PPARγ had a bright start but soon lost their appeal because of undesirable side effects. Subtle modifications may once again make them suitable for treating diabetes.

    • Riekelt H. Houtkooper
    • Johan Auwerx
    News & Views
    Nature
    Volume: 466, P: 443-444

  • Understanding the genetic and phenotypic architecture of health and disease is vital to the identification of novel therapeutic targets and therapies. Here, Nadeau and Auwerx review the fundamentals of genotype–phenotype relations in mouse models and discuss how the integration of human and mouse genetic research remains essential to understanding disease pathogenesis, identifying potential therapeutic targets and developing new therapies

    • Joseph H. Nadeau
    • Johan Auwerx
    Reviews
    Nature Reviews Drug Discovery
    Volume: 18, P: 255-272

  • Enormous differences exist between human studies, which show a strong association of low vitamin D status with obesity, and mouse data, where low vitamin D signalling causes resistance to obesity. Understanding these discrepancies may provide better insight into the spectrum of activities of vitamin D and should be of interest considering the world epidemic of obesity and the metabolic syndrome.

    • Roger Bouillon
    • Geert Carmeliet
    • Annemieke Verstuyf
    Reviews
    Nature Reviews Endocrinology
    Volume: 10, P: 79-87

  • Hepatic steatosis is prevalent in individuals with obesity and is a risk factor for type 2 diabetes mellitus. In this Review, the authors discuss the disruption of endoplasmic reticulum function in hepatic steatosis and how cellular stress responses to lipid accumulation can promote or inhibit progression to severe liver pathologies.

    • Andrei Baiceanu
    • Pierre Mesdom
    • Fabienne Foufelle
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 710-722

  • Mitochondrial proteases can be classified into subgroups depending on their function and location. They are highly specific and modulate biochemical activities that are essential for mitochondrial function and integrity. Impaired or dysregulated function of mitoproteases is associated with ageing and longevity, as well as with pathological conditions and human hereditary diseases.

    • Pedro M. Quirós
    • Thomas Langer
    • Carlos López-Otín
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 345-359