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Showing 1–2 of 2 results
Advanced filters: Author: "Johannes Meiser" Clear advanced filters

  • In this study, Green, Marttila, Kiweler et al. characterize one-carbon metabolism rewiring in response to a dual MTHFD1 and MTHFD2 inhibitor. This work provides insight into one-carbon fluxes, and reveals a previously uncharacterized vulnerability in cancer cells created by folate trapping.

    • Alanna C. Green
    • Petra Marttila
    • Johannes Meiser
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 642-659

  • Chemotherapeutic antifolates, such as methotrexate (MTX), impair cancer cell proliferation by inhibiting nucleotide synthesis. Here, the authors show that MTX sustains an autarkic mitochondrial one-carbon metabolism leading to serine synthesis to promote cancer cell migration and metastasis.

    • Nicole Kiweler
    • Catherine Delbrouck
    • Johannes Meiser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17