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Showing 1–8 of 8 results
Advanced filters: Author: "John D. Lambris" Clear advanced filters

  • The complement system is an essential and efficient component of the immune system's antimicrobial machinery, but many pathogens have developed parallel routes of escape. Understanding complement processes and interactions on a molecular level is essential for the development of novel therapies, and this Review provides a comprehensive overview and update of recent developments in this field.

    • John D. Lambris
    • Daniel Ricklin
    • Brian V. Geisbrecht
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 132-142

  • Synergistic and antagonistic signalling crosstalk between receptors of the innate immune system maintains a fine balance between protective immunity and inflammatory pathology. This Review article looks at how pathogens can manipulate this signalling crosstalk to dysregulate the host immune response for their benefit.

    • George Hajishengallis
    • John D. Lambris
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 187-200

  • Complement is intricately involved in inflammatory processes, yet the mechanisms that modulate the actions of its key mediator C5a are poorly understood. A new study uncovers a molecular partnership between three neutrophil receptors in the recognition of differentially glycated immune complexes and sheds light on regulatory processes in autoimmune and inflammatory disorders (pages 1401–1406).

    • Daniel Ricklin
    • Edimara S Reis
    • John D Lambris
    News & Views
    Nature Medicine
    Volume: 18, P: 1340-1341

  • If research and technology are to become the driving force for turning Greece into a productive society, evidence-based governance, strategic restructuring of infrastructure and a substantial inflow of fresh human capital is urgently needed.

    • George Kollias
    • John D Lambris
    Comments & Opinion
    Nature Immunology
    Volume: 16, P: 1206-1208

  • The functions of the complement system are diverse and extend beyond its role in host defence; complement activation is now known to contribute to numerous immunological, inflammatory and age-related conditions, including kidney disorders. Here, John Lambris and colleagues discuss the key activating, regulatory, and effector mechanisms of the complement system. They highlight important crosstalk connections with other regulatory systems, and, with a focus on kidney disease and transplantation, describe the involvement of complement in clinical conditions as well as promising therapeutic approaches.

    • Daniel Ricklin
    • Edimara S. Reis
    • John D. Lambris
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 383-401

  • This Review focuses on how the complement cascade can both promote and inhibit antitumour immune responses. The authors discuss the potential of targeting complement components for immunotherapeutic purposes in patients with cancer.

    • Edimara S. Reis
    • Dimitrios C. Mastellos
    • John D. Lambris
    Reviews
    Nature Reviews Immunology
    Volume: 18, P: 5-18

  • Complement activation has important physiological and pathological implications for kidney-related and other diseases. Here, the authors discuss the state of the art of complement therapeutics, including the targets, candidate drugs, insights from clinical trials and evolving challenges for the field.

    • Daniel Ricklin
    • Dimitrios C. Mastellos
    • John D. Lambris
    Reviews
    Nature Reviews Nephrology
    Volume: 14, P: 26-47