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Showing 1–12 of 12 results
Advanced filters: Author: "John J O'Shea" Clear advanced filters

  • The recent re-evaluation of the concept that CD4+T helper cell subsets are irreversibly differentiated lineages has become one of the most hotly debated issues in immunology. Here, four leaders in the field provide their thoughts on the complexities and controversies surrounding the functional plasticity of T cell subsets.

    • Jeffrey A. Bluestone
    • Charles R. Mackay
    • Brigitta Stockinger
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 811-816

  • This report highlights the lively debate and discussions on lymphocyte plasticity and/or determinism that occurred at the second Ringberg Colloquium in February 2008 in the Bavarian hills near Tegernsee, Germany.

    • John J O'Shea
    • Christopher A Hunter
    • Ronald N Germain
    News & Views
    Nature Immunology
    Volume: 9, P: 450-453

  • This Review describes how next-generation sequencing has enriched our knowledge of how STAT proteins regulate cytokine-mediated T helper cell differentiation through direct DNA binding and by affecting epigenetic modifications.

    • John J. O'Shea
    • Riitta Lahesmaa
    • Yuka Kanno
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 239-250

  • A new subset of interleukin 17–producing CD4+ helper T cells with diverse functions has now been identified. New work by three groups substantially broadens the understanding of these cells in both mice and humans.

    • Arian Laurence
    • John J O'Shea
    News & Views
    Nature Immunology
    Volume: 8, P: 903-905

  • Interleukin-22, a component of the immune system most studied for its role in autoimmunity, has a more beneficial side. Two studies show how this cytokine fights off microbes in the mucosa of the lung and gut (pages 275–281 and 282–289).

    • Arian Laurence
    • John J O'Shea
    • Wendy T Watford
    News & Views
    Nature Medicine
    Volume: 14, P: 247-249

  • Janus kinases (JAKs) are essential signalling mediators downstream of many pro-inflammatory cytokines. Jakinibs — small-molecule inhibitors of JAKs — have gained traction as safe and efficacious options for the treatment of inflammation-driven pathologies. This Review discusses the biology, development and efficacy of jakinibs in the treatment of immune and inflammatory diseases.

    • Daniella M. Schwartz
    • Yuka Kanno
    • John J. O'Shea
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 843-862

  • The ability of sodium chloride to induce enzymatic activity that leads to the generation of pathogenic TH17 immune cells implicates salt as a possible factor that might exacerbate autoimmune disease. See Letters p.513 & p.518

    • John J. O'Shea
    • Russell G. Jones
    News & Views
    Nature
    Volume: 496, P: 437-439

  • The chromatin signature of genomic enhancers in CD4+ T cells distinguishes asthmatic patients from healthy subjects.

    • Golnaz Vahedi
    • Arianne C Richard
    • John J O'Shea
    News & Views
    Nature Immunology
    Volume: 15, P: 701-703

  • Advances in our understanding of immune cell receptors and the development of biologic agents targeting them have revolutionized the treatment of rheumatoid arthritis (RA). Now, inhibitors of kinases integral to the signalling pathways downstream of these receptors have been added to the therapeutic armamentarium. This Review discusses the signalling pathways and small-molecule inhibitors of their component kinases that have already shown, or are predicted to show, promise in the treatment of RA.

    • John J. O'Shea
    • Arian Laurence
    • Iain B. McInnes
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 173-182