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Showing 1–3 of 3 results
Advanced filters: Author: "John Kappler" Clear advanced filters

  • Current therapies for RA focus on inhibition of synovitis, but do not adequately repair the bone damage that results from the imbalance of the osteoblast–osteoclast axis. Targeting key molecules involved in osteoclastogenesis and osteoblastogenesis might reduce bone destruction and enhance repair of erosions in this disease.

    • Yongwon Choi
    • Joseph R. Arron
    • Michael J. Townsend
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 543-548

  • To avoid potential damage to the host, an inflammatory response is rapidly mobilized on detection of intracellular signals that are released from dying cells. Much has been learned about these 'danger' signals, but several key issues remain unresolved, as discussed by the authors.

    • Hajime Kono
    • Kenneth L. Rock
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 279-289