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Showing 1–3 of 3 results
Advanced filters: Author: "John L Rinn" Clear advanced filters

  • Recent advances in RNA-sequencing technologies have led to the discovery of thousands of previously unannotated noncoding transcripts, including many long noncoding RNAs (lncRNAs) whose functions remain largely unknown. Here, the authors discuss considerations and best practices when identifying and annotating lncRNAs that should aid their functional and mechanistic exploration.

    • John S Mattick
    • John L Rinn
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 22, P: 5-7

  • An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.

    • Loyal A Goff
    • John L Rinn
    News & Views
    Nature Structural & Molecular Biology
    Volume: 20, P: 1344-1346

  • MicroRNAs and long non-coding RNAs regulate diverse aspects of animal embryogenesis. Recent evidence from several species shows their importance in driving and maintaining cell fate decisions, from early patterning through to tissue specification and morphogenesis.

    • Andrea Pauli
    • John L. Rinn
    • Alexander F. Schier
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 136-149