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Showing 1–6 of 6 results
Advanced filters: Author: "John Q. Trojanowski" Clear advanced filters

  • Prion-like propagation of pathogenic proteins has been suggested to underlie several neurodegenerative diseases. In this Perspectives article, Braak et al. posit that progressive lesions in amyotrophic lateral sclerosis (ALS) spread through cell-to-cell transfer of 43-kDA transactive response DNA-binding protein, mainly through cortical neuronal projections to other brain areas and the spinal cord. This model could have important implications for our understanding of ALS and approach to treatment.

    • Heiko Braak
    • Johannes Brettschneider
    • Kelly Del Tredici
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 708-714

  • Many cases of Parkinson's disease (PD) are characterized by not only deficits in movement but also cognitive dysfunction, which can develop into dementia. Here, Irwinet al. review the complex connections between the neuropathological aetiologies that underlie the cognitive deficits associated with PD.

    • David J. Irwin
    • Virginia M.-Y. Lee
    • John Q. Trojanowski
    Reviews
    Nature Reviews Neuroscience
    Volume: 14, P: 626-636

  • Misfolded tau is found in a number of neurodegenerative diseases, including Alzheimer's disease, and could lead to neuronal dysfunction, owing to the formation of toxic species or loss of normal tau function. Given the recent failures of amyloid-β-targeted therapies, the tau-directed drug discovery programmes reviewed here could be an alternative strategy for the treatment of Alzheimer's disease.

    • Kurt R. Brunden
    • John Q. Trojanowski
    • Virginia M.-Y. Lee
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 783-793

  • Various neurodegenerative diseases are characterized by aggregates of pathological proteins, and increasing evidence suggests these disease-associated proteins may 'spread' via neuronal connections. Trojanowski and colleagues describe the molecular mechanisms of such spreading, and present the findings from neuropathological and imaging studies in humans that support this process.

    • Johannes Brettschneider
    • Kelly Del Tredici
    • John Q. Trojanowski
    Reviews
    Nature Reviews Neuroscience
    Volume: 16, P: 109-120

  • TAR DNA-binding protein 43 (TDP-43) inclusions are the main histopathological feature of amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar degeneration (FTLD). In this article, Chen-Plotkinet al. examine the TDP-43 pathology found in these and other neurodegenerative diseases. They also argue for ALS and FTLD with TDP-43 inclusions to be considered as two ends of a continuum of disease that is characterized by TDP-43-mediated neurodegeneration.

    • Alice S. Chen-Plotkin
    • Virginia M.-Y. Lee
    • John Q. Trojanowski
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 211-220

  • Biomarkers to diagnose neurodegenerative disorders early in their course and to monitor responses of patients to therapeutic interventions are urgently needed to optimize the development and application of novel disease-modifying drugs. Trojanowski and colleagues discuss progress and key issues in the discovery and validation of such biomarkers, with a focus on Alzheimer's disease.

    • Leslie M. Shaw
    • Magdalena Korecka
    • John Q. Trojanowski
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 295-303