Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of the Hedgehog (Hh) and Wnt–β-catenin pathways. This Review examines the central part that KRAS plays in the biology of PDAC, and how the timing and location of Hh and Wnt–β-catenin signalling dictate the specification and oncogenic properties of PDAC.
- John P. Morris IV
- Sam C. Wang
- Matthias Hebrok
