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Showing 1–2 of 2 results
Advanced filters: Author: "Jonathan D Rohrer" Clear advanced filters

  • This Case Study describes in detail a case of progranulin-associated frontotemporal lobar degeneration (FTLD). The patient was initially asymptomatic, but developed progressive brain atrophy and deficits on neuropsychological testing before the clinical onset of cognitive impairment. The authors use this case as a springboard to discuss advances in the genetics of FTLD with an emphasis on the importance of serial cognitive testing and neuroimaging.

    • Jonathan D Rohrer
    • Jason D Warren
    • Nick C Fox
    Reviews
    Nature Clinical Practice Neurology
    Volume: 4, P: 455-460

  • Reliable biomarkers for frontotemporal dementia (FTD) are required for accurate discrimination between dementia types, prediction of clinical progression and tailoring of pharmacological interventions. This Review discusses the increasing number of available biomarkers for FTD — including novel imaging modalities and fluid biomarkers — and the future challenges in their implementation.

    • Lieke H. Meeter
    • Laura Donker Kaat
    • John C. van Swieten
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 406-419