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Showing 1–12 of 12 results
Advanced filters: Author: "Joseph Bondy-Denomy" Clear advanced filters

  • Mobile genetic elements have evolved anti-CRISPR (Acr) proteins to bypass the immunity provided by prokaryotic CRISPR–Cas systems. Here, the authors identify 11 type I Acrs encoded on mobile genetic elements, and show that acr loci neighborhoods can be used to discover inhibitors of other bacterial defense systems.

    • Rafael Pinilla-Redondo
    • Saadlee Shehreen
    • Joseph Bondy-Denomy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • A phage genetic engineering platform will enable a better understanding of phage biology and engineering of phage therapies.

    • Jingwen Guan
    • Agnès Oromí-Bosch
    • Joseph Bondy-Denomy
    Research
    Nature Microbiology
    Volume: 7, P: 1956-1966

  • A search for genes encoding anti-CRISPR (Acr) proteins on plasmids and other conjugative elements identifies new Acrs that regulate plasmid dissemination and are broad-spectrum inhibitors of Cas9 in human cells.

    • Caroline Mahendra
    • Kathleen A. Christie
    • Joseph Bondy-Denomy
    Research
    Nature Microbiology
    Volume: 5, P: 620-629

  • Bacteriophages fight back with the double whammy of an anti-CRISPR protein and integration into the CRISPR array to protect themselves from the CRISPR–Cas9 immune system of Streptococcus pyogenes.

    • Joseph Bondy-Denomy
    News & Views
    Nature Microbiology
    Volume: 6, P: 1475-1476

  • In this study Fossati et al. demonstrate how co-fractionation mass spectrometry can be applied to systematically investigate pathogen proteome organization and host interactome plasticity upon Jumbophage infection of Pseudomonas aeruginosa.

    • Andrea Fossati
    • Deepto Mozumdar
    • Danielle L. Swaney
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The jumbo phage ΦKZ constructs a proteinaceous nucleus-like compartment around its genome that protects phage DNA from degradation by DNA-targeting immune effectors of the host, including CRISPR–Cas and restriction enzymes.

    • Senén D. Mendoza
    • Eliza S. Nieweglowska
    • Joseph Bondy-Denomy
    Research
    Nature
    Volume: 577, P: 244-248

  • The identification of the KinB–AlgB two-component system, known to modulate alginate biosynthesis, together with downstream proteins that repress the Type I-F CRISPR–Cas system in Pseudomonas aeruginosa, elucidates how bacteria control the expression of nucleolytic host defence systems to minimize the potential risks of self-targeting.

    • Adair L. Borges
    • Bardo Castro
    • Joseph Bondy-Denomy
    Research
    Nature Microbiology
    Volume: 5, P: 679-687

  • Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aeruginosa may also be involved in post-transcriptional regulation of virulence.

    • Blake Wiedenheft
    • Joseph Bondy-Denomy
    Research Highlights
    Cell Research
    Volume: 27, P: 163-164